Lycopene Reduces Lung Injury in Rabbits
Author Information
Author(s): Fioretto José Roberto, Klefens Susiane Oliveira, Carpi Mário Ferreira, Moraes Marcos Aurélio, Bonatto Rossano César, Ferreira Ana Lúcia Anjos, Corrêa Camila Renata, Kurokawa Cilmery Suemi, Ronchi Carlos Fernando
Primary Institution: Universidade Estadual Paulista “Júlio de Mesquita Filho”
Hypothesis
Does lycopene supplementation reduce inflammation and DNA damage in an acute lung injury model?
Conclusion
Lycopene supplementation reduces inflammatory and histopathological lung injuries and improves oxygenation in rabbits with acute lung injury.
Supporting Evidence
- Lycopene supplementation significantly increased plasma lycopene concentration.
- Rabbits receiving lycopene had significantly less inflammation and histological injury.
- DNA damage was significantly reduced in rabbits supplemented with lycopene.
Takeaway
Giving rabbits lycopene, a substance found in tomatoes, helps their lungs heal better when they are hurt.
Methodology
Rabbits were supplemented with 10mg/kg lycopene for 21 days before inducing lung injury and assessed for inflammation and DNA damage.
Limitations
The study duration was limited to four hours, and the effects of cytokines were not measured.
Participant Demographics
Male Norfolk white rabbits weighing 2.0 - 3.0 kg.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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