Oncogene Overexpression in Astrocytic Gliomas
Author Information
Author(s): J.M. Orian, K. Vasilopoulos, S. Yoshida, A. H. Kaye, C.W. Chow, M.F. Gonzales
Primary Institution: University of Melbourne
Hypothesis
Is there an association between the expression of oncogenes and the histological grade of astrocytic gliomas?
Conclusion
The study found that overexpression of c-myc and Ha/N-ras oncogenes is indicative of tumor progression in astrocytic gliomas.
Supporting Evidence
- 95% of low grade tumors showed overexpression of c-erbB-1.
- 76% of glioblastoma multiforme tumors overexpressed c-myc.
- 71% of glioblastoma multiforme tumors overexpressed Ha/N-ras.
- Co-overexpression of oncogenes increased with tumor grade.
Takeaway
This study looked at brain tumors called astrocytomas and found that certain genes are more active in more serious cases, which might help doctors understand how bad the tumors are.
Methodology
The study used immunogold silver histochemistry to analyze the expression of four oncogenes in tumor samples.
Limitations
The study is cross-sectional and cannot establish causation or progression over time.
Participant Demographics
The study included 62 astrocytomas of varying grades: 20 low grade, 21 intermediate grade, and 21 high grade.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI; 5,51
Statistical Significance
p<0.001
Want to read the original?
Access the complete publication on the publisher's website