Smad7 induces hepatic metastasis in colorectal cancer
2008
Smad7 Induces Liver Metastasis in Colorectal Cancer
Sample size: 18
publication
Evidence: high
Author Information
Author(s): Halder S K, Rachakonda G, Deane N G, Datta P K
Primary Institution: Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine
Hypothesis
The study aims to understand the role of Smad7 in the metastasis of colorectal cancer to the liver.
Conclusion
The study demonstrates that overexpression of Smad7 in colon cancer cells promotes liver metastasis.
Supporting Evidence
- 17 out of 18 control mice did not show any metastasis in the liver.
- 76% of mice from Smad7-expressing clones produced liver metastases.
- Smad7 overexpression was verified by western blot analyses.
Takeaway
When certain cancer cells have too much Smad7, they can spread to the liver and grow there.
Methodology
The study used a splenic injection model in athymic nude mice to assess liver metastasis from colon adenocarcinoma cells expressing Smad7.
Participant Demographics
Athymic nude mice were used in the study.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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