Intra-arterial Cocktail Therapy for Stroke Patients
Author Information
Author(s): Zhao Zi-Ai, Hu Hai-Zhou, Li Wei, Qiu Jing, Zhao Yong-Gang, Nguyen Thanh N., Chen Hui-Sheng
Primary Institution: General Hospital of Northern Theater Command, Shenyang, China
Hypothesis
Can intra-arterial cocktail therapy improve outcomes in patients with anterior circulation large vessel occlusion after endovascular reperfusion?
Conclusion
Intra-arterial cocktail therapy may be safe and feasible but did not improve 90-day functional outcomes in stroke patients.
Supporting Evidence
- The INSIST-CT trial included 30 patients in the treatment group and 261 in the control group.
- The primary outcome was a modified Rankin Scale score of 0–2 at 90 days.
- The proportion of favorable outcomes was 60% in the INSIST-CT group compared to 55.9% in the control group.
- No significant difference in symptomatic intracranial hemorrhage was observed between the two groups.
- Propensity score matching and inverse probability of treatment weighting analyses showed similar results.
Takeaway
Doctors tested a new treatment for stroke patients to see if it helps them recover better after a procedure. It didn't make a big difference, but it seemed safe.
Methodology
This was a prospective, single-arm, pilot study with a control group for comparison.
Potential Biases
Potential bias from the single-arm design and retrospective control group.
Limitations
The study was single-arm with a small sample size and potential biases due to the lack of a concurrent control group.
Participant Demographics
Patients with anterior circulation large vessel occlusion who underwent endovascular treatment.
Statistical Information
P-Value
0.41
Confidence Interval
95% CI 0.62–3.26
Statistical Significance
p=0.41
Digital Object Identifier (DOI)
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