Cerebral Autoregulation After Intracerebral Hemorrhage
Author Information
Author(s): Nakagawa Kazuma, Serrador Jorge M, LaRose Sarah L, Sorond Farzaneh A
Primary Institution: Neuroscience Institute, The Queen's Medical Center, Honolulu, Hawaii, USA
Hypothesis
Dynamic cerebral autoregulation may be less effective in patients with intracerebral hemorrhage compared to healthy controls.
Conclusion
Patients with intracerebral hemorrhage had higher gains in a wide range of frequency ranges compared to controls, suggesting impaired dynamic cerebral autoregulation.
Supporting Evidence
- The ICH group demonstrated higher cerebrovascular resistance index compared to controls.
- The ICH group had higher gains in both low and high frequency ranges compared to controls.
- The study suggests that dynamic cerebral autoregulation may be less effective in the early days after ICH.
Takeaway
This study looked at how well the brain controls blood flow after a type of brain bleed. It found that people with this condition have a harder time keeping blood flow steady compared to healthy people.
Methodology
Twenty-one patients with early lobar or basal ganglia intracerebral hemorrhage were compared to twenty-three age-matched controls using transcranial Doppler ultrasound to measure blood flow and pressure.
Potential Biases
Potential unaccounted factors in the intensive care unit may have affected the results.
Limitations
The study lacked a control group with similar vascular risk factors and was conducted over a range of 72 hours from the ictus, which may have combined different stages of ICH.
Participant Demographics
21 patients with lobar or basal ganglia ICH (mean age 66 ± 15 years) and 23 age-matched healthy controls (mean age 65 ± 9 years).
Statistical Information
P-Value
p = 0.04
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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