Using Injectable Platelet-Rich Fibrin for Drug Delivery in Gum Treatment
Author Information
Author(s): Thamaraiselvan Murugan, Jayakumar Nadathur Doraisamy
Primary Institution: Saveetha Dental College & Hospitals, Saveetha Institute of Medical and Technical Sciences
Hypothesis
Can ciprofloxacin-loaded injectable platelet-rich fibrin (i-PRF) improve outcomes in non-surgical periodontal pocket therapy?
Conclusion
Injectable platelet-rich fibrin (i-PRF) is a promising vehicle for delivering ciprofloxacin in periodontal pocket therapy, leading to significant clinical improvements.
Supporting Evidence
- All treatment groups showed significant improvements in clinical and microbial parameters.
- Group 1 had the highest reduction in probing depth and gingival index.
- Injectable platelet-rich fibrin is autologous and easy to handle.
- Ciprofloxacin-loaded i-PRF resulted in significant microbial reduction.
- Participants reported no adverse reactions during the study.
- Clinical attachment gain was highest in the ciprofloxacin-loaded group.
- i-PRF showed sustained release of the drug over time.
- Study followed CONSORT guidelines for clinical trials.
Takeaway
This study tested a new way to deliver medicine directly to infected gums using a special gel made from blood, which helped patients heal better.
Methodology
A randomized controlled trial with 79 periodontal pocket sites divided into three groups receiving different treatments, followed by clinical and microbial assessments.
Potential Biases
Potential selection bias was minimized by randomization and blinding.
Limitations
Short follow-up duration and lack of a positive control group.
Participant Demographics
Participants aged 30-60 years with Stage II Grade B periodontitis.
Statistical Information
P-Value
0.002
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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