Tumour cell thrombospondin-1 regulates tumour cell adhesion and invasion through the urokinase plasminogen activator receptor
2000
Thrombospondin-1 and Tumor Cell Behavior
publication
Author Information
Author(s): Albo D, Rothman V L, Roberts D D, Tuszynski G P
Primary Institution: MCP Hahnemann University
Hypothesis
Tumor cell-produced thrombospondin-1 regulates tumor cell adhesion and invasion through the urokinase plasminogen activator receptor.
Conclusion
Tumor cell-produced thrombospondin-1 plays a critical role in regulating tumor cell adhesion and invasion.
Supporting Evidence
- Tumor cell thrombospondin-1 induced a 2–7 fold increase in urokinase plasminogen activator receptor expression.
- There was a 50–65% increase in cell-associated urokinase plasminogen activator and plasmin activities.
- Thrombospondin-1 promoted tumor cell invasion and decreased tumor cell adhesion.
Takeaway
This study found that a protein made by tumor cells helps them stick and move around, which could affect how cancer spreads.
Methodology
The study involved THBS-1-transfected MDA-MB-435 breast cancer cells and assessed adhesion and invasion through various assays.
Digital Object Identifier (DOI)
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