Unique Effector Memory Lymphocytes Identified by CD146
Author Information
Author(s): Elshal Mohamed F, Khan Sameena S, Raghavachari Nalini, Takahashi Yoshiyuki, Barb Jennifer, Bailey James J, Munson Peter J, Solomon Michael A, Danner Robert L, McCoy J Philip Jr
Primary Institution: National Institutes of Health
Hypothesis
What is the role of CD146 expression on lymphocytes in healthy individuals?
Conclusion
CD146 identifies a small population of T and B lymphocytes with characteristics of effector memory cells that may be primed for inflammation.
Supporting Evidence
- CD146 was found on a small percentage of T, B, and NK cells in healthy individuals.
- CD146+ T cells showed enhanced adherence to endothelial cells in vitro.
- Gene profiling revealed distinct differences between CD146+ and CD146- T cells.
Takeaway
Some special immune cells in our blood have a marker called CD146, which helps them stick to blood vessels and may help them move to areas where there's inflammation.
Methodology
Lymphocytes from healthy donors were analyzed for CD146 expression using flow cytometry and gene profiling.
Limitations
The study primarily involved healthy individuals, and the implications for disease states remain to be fully explored.
Participant Demographics
Healthy individuals, specific demographics not detailed.
Statistical Information
P-Value
0.005
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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