MSN2 and MSN4 Link Calorie Restriction and TOR to Sirtuin-Mediated Lifespan Extension in Saccharomyces cerevisiae
2007
Linking Calorie Restriction and TOR to Lifespan Extension in Yeast
publication
Evidence: high
Author Information
Author(s): Oliver Medvedik, Dudley W. Lamming, D. W. Kim, David A. Sinclair
Primary Institution: Harvard Medical School
Hypothesis
Does TOR inhibition extend lifespan in yeast by the same mechanism as calorie restriction?
Conclusion
Both calorie restriction and TOR inhibition extend lifespan in yeast by increasing the activity of sirtuins and stabilizing the rDNA locus.
Supporting Evidence
- Caloric restriction has been shown to extend lifespan in various species.
- TOR signaling is a nutrient-responsive pathway that regulates lifespan.
- MSN2 and MSN4 are transcription factors that relocalize to the nucleus during calorie restriction.
Takeaway
Eating less can help yeast live longer, and stopping a certain cell signal can do the same thing by helping the yeast's cells stay healthy.
Methodology
The study used yeast strains to investigate the roles of MSN2 and MSN4 in lifespan extension through calorie restriction and TOR inhibition.
Digital Object Identifier (DOI)
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