Cardiovascular Treatment Targets and Kidney Problems in High-Risk Patients
Author Information
Author(s): Selvarajah Sharmini, vD Graaf Yolanda, Visseren Frank LJ, Bots Michiel L
Primary Institution: University Medical Center Utrecht
Hypothesis
Do recommended treatment targets for cardiovascular disease reduce the risk of renal complications in high-risk patient populations?
Conclusion
Clinical guidelines for cardiovascular disease management do reduce the risk of renal complications in high-risk patients, with benefits seen from achieving any two treatment targets.
Supporting Evidence
- The incidence rate for end stage renal failure and renal atherosclerotic disease reduced linearly with each additional treatment target achieved.
- Achievement of any two treatment targets reduced the risk of renal complications.
- For patients with clinically manifest vascular disease and diabetes, the hazard ratios were 0.56 and 0.28 respectively.
Takeaway
If doctors help patients reach their health goals for heart problems, it can also help their kidneys stay healthy.
Methodology
This was a cohort study involving patients at risk of or with cardiovascular disease, assessing the relationship between treatment targets achieved and renal complications.
Limitations
The number of treatment targets achieved was only assessed at baseline, and the follow-up duration may have been insufficient for observing end-stage renal failure development.
Participant Demographics
The cohort consisted of 7,208 participants, with a median age of 57 years and 67% male; 1,759 were diabetics and 4,859 had clinically manifest vascular disease.
Statistical Information
P-Value
<0.001
Confidence Interval
95% CI 0.26-0.82
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website