Regulation of Src Family Kinases in Human Cancers
2011
Regulation of Src Family Kinases in Human Cancers
publication
Evidence: high
Author Information
Author(s): Banibrata Sen, Faye M. Johnson
Primary Institution: The University of Texas MD Anderson Cancer Center
Hypothesis
The activation of Src in human cancers may occur through a variety of mechanisms that include domain interaction and structural remodeling.
Conclusion
Src is a promising target for cancer therapy due to its roles in invasion, tumor progression, and metastasis.
Supporting Evidence
- Src plays a crucial role in cell division, motility, adhesion, and survival in both normal and cancer cells.
- Several small molecule inhibitors of Src are currently being investigated in clinical trials.
- Src activation is common in various types of cancers, although activating mutations are rare.
Takeaway
Src is a protein that helps cancer cells grow and spread, and scientists are looking for ways to block it to treat cancer.
Methodology
The article summarizes mechanisms regulating Src kinase activity and discusses the status of Src inhibitor development against various types of cancers.
Digital Object Identifier (DOI)
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