Probiotic Lactobacilli Protect Cells from Pathogen-Induced Death
Author Information
Author(s): Kiousi Despoina Eugenia, Panopoulou Maria, Pappa Aglaia, Galanis Alex
Primary Institution: Democritus University of Thrace, Alexandroupolis, Greece
Hypothesis
Can Lactiplantibacillus plantarum L125 and Lactiplantibacillus pentosus L33 protect human colon cells from cell death caused by Staphylococcus aureus and Escherichia coli?
Conclusion
Lactiplantibacillus plantarum L125 significantly protects human colon cells from pathogen-induced cell death through direct contact and competitive exclusion.
Supporting Evidence
- Lactiplantibacillus plantarum L125 reduced pathogen-induced cell death in HT-29 cells.
- L125 significantly decreased the adherence of Staphylococcus aureus to HT-29 cells.
- L125's protective effects were comparable to those of Lacticaseibacillus rhamnosus GG.
Takeaway
Some good bacteria can help keep our cells safe from bad germs that can make us sick.
Methodology
The study used in vitro experiments with human colon adenocarcinoma cells to assess the protective effects of probiotic strains against pathogens.
Limitations
The study primarily focused on in vitro models, which may not fully replicate in vivo conditions.
Participant Demographics
Human colon adenocarcinoma cell line HT-29 was used.
Statistical Information
P-Value
<0.005
Statistical Significance
p<0.005
Digital Object Identifier (DOI)
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