Serum Markers in Neonatal Late-Onset Sepsis
Author Information
Author(s): Birsen Ucar, Bilal Aksit, M. Arif Yarar, Coskun Colak, Omer Akbay, Yildiz Colak, Ertugrul
Primary Institution: Eskisehir Osmangazi University
Hypothesis
The study aims to evaluate the value of serum amyloid A (SAA) and procalcitonin (PCT) in the diagnosis and follow-up of neonatal late-onset sepsis (NLS).
Conclusion
CRP is the most reliable marker for diagnosing NLS, while PCT and TNF-α may also be useful, but SAA and IL-1β are not reliable markers.
Supporting Evidence
- CRP levels were significantly higher in septic neonates compared to controls.
- PCT and TNF-α also showed significant differences on day 0.
- SAA and IL-1β levels did not differ significantly from healthy neonates.
Takeaway
Doctors looked at blood tests to find out if sick newborns had an infection called sepsis. They found that one test (CRP) was really good at showing if there was an infection.
Methodology
The study included 36 septic and healthy newborns, measuring various serum markers on days 0, 4, and 8.
Limitations
The study did not find significant differences in SAA levels between septic and healthy newborns.
Participant Demographics
36 newborns with suspected NLS and 36 healthy controls.
Statistical Information
P-Value
P = .001
Confidence Interval
95% CI: 85.4–99.5
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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