Measuring Selection in Experimental Evolution
Author Information
Author(s): Luis-Miguel Chevin
Primary Institution: Imperial College London
Hypothesis
How can we accurately measure selection coefficients in evolution experiments?
Conclusion
Inconsistencies in measuring selection coefficients hinder proper comparison across species, particularly when using relative Malthusian fitness.
Supporting Evidence
- Distributions of mutation fitness effects are being measured in a growing number of organisms.
- The use of relative Malthusian fitness results in overestimating the per-generation strength of selection.
- The fitness effects of mutations across species should be re-examined.
Takeaway
This study talks about how scientists measure the effects of mutations on fitness in experiments, and why some methods might give wrong results.
Methodology
The article discusses the definitions and measurements of selection coefficients in evolution experiments.
Potential Biases
Using relative Malthusian fitness can lead to overestimating the strength of selection.
Limitations
The study highlights the lack of consistency in measuring selection coefficients across different studies.
Digital Object Identifier (DOI)
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