Resistant Starch and Exercise Help Prevent Weight Regain in Obese Rats
Author Information
Author(s): Janine A. Higgins, Matthew R. Jackman, Ian L. Brown, Ginger C. Johnson, Amy Steig, Holly R. Wyatt, James O. Hill, Paul S. MacLean
Primary Institution: Center for Human Nutrition, Anschutz Medical Campus, University of Colorado Denver
Hypothesis
Dietary resistant starch (RS) and exercise will independently and synergistically decrease the rate of weight regain in a rat model of obesity.
Conclusion
Both resistant starch and exercise independently help reduce weight regain after weight loss in obese rats.
Supporting Evidence
- Rats that consumed resistant starch regained less weight compared to those that did not.
- Exercise reduced the rate of weight regain in the initial days of relapse.
- Combining resistant starch with exercise led to better maintenance of lean mass during weight regain.
- Exercise cessation resulted in increased weight gain and fat accumulation.
- Resistant starch lowered insulin levels during the early stages of weight regain.
Takeaway
Feeding rats resistant starch and making them exercise helps them keep off weight after they lose it, even when they eat a lot of fat.
Methodology
Obesity-prone rats were weight reduced and then allowed to relapse on a high fat diet with varying levels of resistant starch, with some groups exercising.
Potential Biases
Potential bias in the selection of rats based on their predisposition to obesity.
Limitations
The study was conducted on rats, which may not fully represent human weight regain dynamics.
Participant Demographics
Male Wistar rats, aged 10 weeks at the start of the study.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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