Loss of heterozygosity at chromosome 1p in different solid human tumours: association with survival
1999
Loss of heterozygosity at chromosome 1p in human tumors and survival
Sample size: 683
publication
Evidence: moderate
Author Information
Author(s): Ragnarsson G, Eiriksdottir G, Johannsdottir J Th, Jonasson J G, Egilsson V, Ingvarsson S
Primary Institution: Department of Pathology, University and National Hospital of Iceland
Hypothesis
Is there an association between loss of heterozygosity at chromosome 1p and survival in different solid human tumors?
Conclusion
Loss of heterozygosity at chromosome 1p is a significant indicator of prognosis in breast cancer patients.
Supporting Evidence
- 54% of the tumors showed loss of heterozygosity at chromosome 1p.
- High percentages of LOH were observed in various tumor types, suggesting the presence of tumor-suppressor genes.
- Distinct patterns of LOH were detected at different tumor locations.
Takeaway
The study found that many tumors lose important genetic information, which can help doctors understand how long patients might live.
Methodology
The distal half of chromosome 1p was analyzed using 15 polymorphic microsatellite markers in 683 human solid tumors.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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