RARRES3 and Colorectal Cancer
Author Information
Author(s): Shyu R-Y, Jiang S-Y, Chou J-M, Shih Y-L, Lee M-S, Yu J-C, Chao P-C, Hsu Y-J, Jao S-W
Primary Institution: Tri-Service General Hospital
Hypothesis
The expression of RARRES3 protein is correlated with tumor differentiation in colorectal adenocarcinoma.
Conclusion
RARRES3 expression is positively correlated with tumor differentiation in colorectal cancer, but it is not a prognostic marker.
Supporting Evidence
- RARRES3 protein is expressed at high levels in normal colorectal mucosa and adenoma tissues.
- Moderately and poorly differentiated colorectal tumors showed a progressive loss of RARRES3 expression.
- The study found no significant association between RARRES3 expression and Dukes' stages.
Takeaway
RARRES3 is a protein that helps keep cells healthy, and in cancer, its levels can show how well the cancer cells are behaving.
Methodology
The study analyzed RARRES3 protein expression in colorectal tissues using immunohistochemistry.
Limitations
The study did not find RARRES3 to be a prognostic marker for colorectal adenocarcinoma.
Participant Demographics
The study included 120 patients with colorectal adenocarcinoma and 20 patients with adenomas, with a mean age of 63.3 years.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website