Microsatellite-stable diploid carcinoma: a biologically distinct and aggressive subset of sporadic colorectal cancer
2001
Distinct and Aggressive Colorectal Cancer Subtype
Sample size: 46
publication
Evidence: moderate
Author Information
Author(s): Hawkins N J, Tomlinson I, Meagher A, Ward R L
Primary Institution: School of Pathology, University of NSW, Sydney, Australia
Hypothesis
Are diploid microsatellite-stable colorectal cancers a distinct and aggressive subset of the disease?
Conclusion
Diploid microsatellite-stable colorectal cancers are a distinct subset associated with early metastases.
Supporting Evidence
- 54% of tumors were aneuploid, while 30% were diploid and microsatellite-stable.
- Diploid microsatellite-stable tumors were associated with metastatic disease at diagnosis.
- Aneuploid tumors were more common in men and likely to be left sided.
Takeaway
Some colorectal cancers are different from others, and this specific type can spread more quickly.
Methodology
Flow cytometry, PCR amplification, and immunostaining were used to analyze tumor characteristics.
Participant Demographics
The study included sporadic colorectal cancer patients, with a notable gender distribution in tumor types.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website