Study of 2-Methyl-4-phenyl-3,4-dihydroquinazoline
Author Information
Author(s): Arto Valkonen, Erkki Kolehmainen, Anna Zakrzewska, Agnieszka Skotnicka, Ryszard Gawinecki
Primary Institution: University of Jyväskylä, Department of Chemistry
Hypothesis
The study investigates the structure and formation of 2-methyl-4-phenyl-3,4-dihydroquinazoline.
Conclusion
The compound exhibits a consistent structure in both solution and crystalline states, with specific intermolecular interactions forming helical chains.
Supporting Evidence
- The compound was formed during the lithiation of 2-methylquinazoline with phenyllithium.
- NMR spectra and X-ray data confirm the structure of the compound.
- The phenyl group is twisted out of the plane of the quinazoline ring system.
Takeaway
The researchers made a new chemical compound and found that it looks the same in liquid and solid forms.
Methodology
The compound was synthesized using phenyllithium and characterized using NMR and X-ray crystallography.
Limitations
No reliable determination of the absolute structure was possible by X-ray crystallography.
Digital Object Identifier (DOI)
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