Taste Masking of Metformin Hydrochloride with Indion 234
Author Information
Author(s): PK Bhoyar, YM Amgaonkar
Primary Institution: S.K.B. College of Pharmacy, Nagpur, Maharashtra, India
Hypothesis
Can metformin hydrochloride be effectively formulated into tasteless complexes using indion 234?
Conclusion
The study found that metformin hydrochloride can be effectively complexed with indion 234 to mask its bitter taste, making it more agreeable for patients.
Supporting Evidence
- The drug release from the DRC was insufficient to impart a bitter taste.
- Volunteers rated the complex as tasteless and agreeable.
- Complete drug release was observed at gastric pH in 3 hours.
Takeaway
Researchers made a special mix of a diabetes medicine that tastes bad, so it doesn't taste bad anymore, helping people take their medicine better.
Methodology
The study involved optimizing the drug loading of metformin onto indion 234 resin and evaluating the taste masking through sensory evaluation and drug release studies.
Limitations
The study primarily focused on a specific resin and may not be generalizable to other taste-masking agents.
Participant Demographics
Nine volunteers participated in the taste evaluation.
Statistical Information
P-Value
< 0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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