Nuclear Trafficking of Secreted Factors and Cell-Surface Receptors
Author Information
Author(s): Planque Nathalie
Primary Institution: Laboratoire d'Oncologie Virale et Moléculaire, Université Paris7-Denis Diderot
Hypothesis
How do secreted factors and cell-surface receptors regulate cell proliferation and differentiation through nuclear trafficking?
Conclusion
Nuclear localization of secreted factors and receptors is linked to cell proliferation, differentiation, and cancer progression.
Supporting Evidence
- Nuclear localization of growth factors and receptors is correlated with tumor progression.
- Nuclear forms of FGF and EGFR regulate transcription of genes involved in cell proliferation.
- Secreted factors can influence DNA repair and RNA metabolism in the nucleus.
- Nuclear trafficking of proteins is linked to resistance to cancer therapies.
Takeaway
Some proteins that are usually outside cells can go inside and even into the cell's control center, the nucleus, where they help cells grow and change.
Methodology
The review discusses various mechanisms of nuclear trafficking and the roles of secreted factors and receptors in cellular processes.
Limitations
The review does not provide experimental data but summarizes existing literature.
Digital Object Identifier (DOI)
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