Effects of Common Polymorphisms in miR-196a2 and miR-146a on Cancer Risk
Author Information
Author(s): Xu Wei, Xu Jijun, Liu Shifeng, Chen Bo, Wang Xueli, Li Yan, Qian Yun, Zhao Weihong, Wu Jianqing
Primary Institution: Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
Hypothesis
This study investigates the association between specific microRNA polymorphisms and cancer susceptibility.
Conclusion
The study suggests that the rs11614913 polymorphism in miR-196a2 is linked to decreased cancer susceptibility, particularly in Asians and breast cancer patients.
Supporting Evidence
- The rs11614913 polymorphism was associated with reduced cancer risk, especially in Asian populations.
- The C allele of rs2910164 was linked to protection from digestive cancers.
- Subgroup analyses indicated significant associations for breast cancer with the T allele of rs11614913.
Takeaway
Some tiny changes in our genes can make us more or less likely to get cancer, and this study looked at two specific changes to see how they affect cancer risk.
Methodology
The study performed a meta-analysis of published studies assessing the association between miR-196a2 and miR-146a polymorphisms and cancer risk.
Potential Biases
The analysis may be affected by the inclusion of only published studies, which could introduce bias.
Limitations
The study's findings may be limited by the heterogeneity among the included studies and the potential for publication bias.
Participant Demographics
The study included participants from various ethnic backgrounds, primarily Asians and Caucasians.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% CI
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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