Natural Products and Breast Cancer: Aromatase Inhibition
Author Information
Author(s): Shabana I. Khan, Jianping Zhao, Ikhlas A. Khan, Larry A. Walker, Asok K. Dasmahapatra
Primary Institution: University of Mississippi
Hypothesis
Natural products can serve as effective regulators of breast cancer-associated aromatase promoters.
Conclusion
Natural products have the potential to inhibit aromatase activity and may serve as safer alternatives to synthetic aromatase inhibitors in breast cancer treatment.
Supporting Evidence
- Natural products are rich in chemopreventive agents that can be used in chemotherapy for hormone-dependent breast cancer.
- Asian women have a lower breast cancer risk, possibly due to dietary factors including phytoestrogens.
- Biochanin A and genistein have shown potential in inhibiting aromatase activity in breast cancer cells.
Takeaway
Some plants can help stop breast cancer by blocking a process that makes estrogen, which can help cancer grow.
Methodology
The review summarizes studies on various phytochemicals and their effects on aromatase promoters.
Limitations
The exact mechanisms of how these natural products inhibit aromatase are not fully understood.
Digital Object Identifier (DOI)
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