Resistance of Pseudomonas aeruginosa to Antibiotics in Kuwait
Author Information
Author(s): Laure Poirel, Vincent O. Rotimi, Eiman M. Mokaddas, Amal Karim, Patrice Nordmann
Primary Institution: Faculte de Medecine Paris-Sud, Le Kremlin-Bicetre, France; Kuwait University, Kuwait
Hypothesis
Are there novel beta-lactamases in Pseudomonas aeruginosa clinical isolates from Kuwait?
Conclusion
Two clinical isolates of Pseudomonas aeruginosa from Kuwait showed resistance to extended-spectrum cephalosporins and a synergistic effect between ceftazidime and clavulanic acid.
Supporting Evidence
- Both P. aeruginosa KU-1 and KU-2 showed decreased susceptibility to all beta-lactams except imipenem and piperacillin/tazobactam.
- Preliminary antibiotic susceptibility testing revealed a slight synergy between ceftazidime and clavulanic acid.
- VEB-1-like sequences shared 99% amino acid identity with VEB-1.
Takeaway
Doctors found two germs in Kuwait that are hard to treat with certain antibiotics, which could make it tough to help sick people.
Methodology
Clinical isolates were obtained from patients, and antibiotic susceptibility testing was performed using disc diffusion and agar dilution methods.
Limitations
The study may underestimate the prevalence of ESBLs due to difficulties in routine detection.
Participant Demographics
One isolate from a 1-day-old infant and another from a 73-year-old man.
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