Endotoxemia related to cardiopulmonary bypass is associated with increased risk of infection after cardiac surgery
2011
Endotoxemia and Infection Risk After Heart Surgery
Sample size: 54
publication
Evidence: moderate
Author Information
Author(s): Klein DJ, Briet F, Nisenbaum R, Romaschin A, Mazer C
Primary Institution: St Michael's Hospital, Toronto, Canada
Hypothesis
Is there a relationship between endotoxemia and postoperative infection in patients undergoing aortocoronary bypass grafting surgery?
Conclusion
Endotoxemia is associated with a significantly increased risk of developing postoperative infections after cardiac surgery.
Supporting Evidence
- Fifty-seven patients were enrolled and 54 patients were analyzable.
- Eight patients developed postoperative infections (14.6%).
- EAA at T2 was strongly correlated with the risk of postoperative infection.
Takeaway
This study found that high levels of a substance called endotoxin are linked to a higher chance of getting infections after heart surgery.
Methodology
A single-center prospective observational study measuring endotoxin activity during the perioperative period for elective aortocoronary bypass grafting.
Statistical Information
P-Value
0.02
Statistical Significance
p=0.02
Digital Object Identifier (DOI)
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