Structural basis for a nucleoporin exportin complex between RanBP2, SUMO1-RanGAP1, the E2 Ubc9, Crm1 and the Ran GTPase
2024
Understanding the Nucleoporin Exportin Complex
publication
Author Information
Author(s): Baytshtok Vladimir, DiMattia Michael A., Lima Christopher D.
Primary Institution: Cold Spring Harbor Laboratory
Hypothesis
The study investigates how the nucleoporin RanBP2 interacts with other proteins to facilitate export processes at the nuclear pore complex.
Conclusion
The study reveals new structural insights into how RanBP2 and its associated proteins function during mitosis.
Supporting Evidence
- RanBP2 interacts with SUMO1-modified RanGAP1 and Ubc9 at the nuclear pore complex.
- The study provides cryo-EM structures of the RanBP2 complex.
- RanBP2's E3 ligase activity is dependent on Crm1 and RanGAP1.
Takeaway
This study looks at how certain proteins work together to help move things in and out of the cell's nucleus, especially during cell division.
Methodology
Cryo-electron microscopy was used to resolve the structures of the RanBP2 complex.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website