Deoxynivalenol Increases Intestinal Inflammation from Salmonella in Pigs
Author Information
Author(s): Vandenbroucke Virginie, Croubels Siska, Martel An, Verbrugghe Elin, Goossens Joline, Van Deun Kim, Boyen Filip, Thompson Arthur, Shearer Neil, De Backer Patrick, Haesebrouck Freddy, Pasmans Frank
Primary Institution: Ghent University
Hypothesis
Does deoxynivalenol (DON) at low concentrations interact with intestinal inflammation induced by Salmonella Typhimurium?
Conclusion
The intake of low concentrations of DON makes the intestinal epithelium more susceptible to Salmonella Typhimurium, leading to increased inflammation.
Supporting Evidence
- DON exposure led to higher levels of inflammatory markers IL-12 and TNFα.
- Salmonella invasion was significantly increased in the presence of DON.
- The study demonstrated that low concentrations of DON can enhance the inflammatory response to Salmonella.
Takeaway
Eating food with a tiny bit of a harmful substance called DON can make it easier for a germ called Salmonella to cause sickness in pigs.
Methodology
The study used a porcine intestinal ileal loop model to assess the interaction between DON and Salmonella Typhimurium.
Limitations
The study was conducted in a porcine model, which may not fully represent human responses.
Participant Demographics
Two 5-week-old pigs were used in the experiments.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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