Cis- and Trans-Acting Elements Regulate the Mouse Psmb9 Meiotic Recombination Hotspot
2007
Regulation of Mouse Psmb9 Meiotic Recombination Hotspot
publication
Evidence: high
Author Information
Author(s): Frédéric Baudat, Bernard de Massy
Primary Institution: Institute of Human Genetics, Centre National de la Recherche Scientifique, Montpellier, France
Hypothesis
What genetic factors control the activity of the meiotic recombination hotspot near the Psmb9 gene in mice?
Conclusion
The study reveals that specific genetic elements can significantly enhance or repress recombination activity at the Psmb9 hotspot in mice.
Supporting Evidence
- The presence of the wm7 haplotype increases CO frequencies at Psmb9 by 2,000-fold or more.
- Recombination initiation is activated in trans by a wm7-specific element.
- A cis-acting repressor on the SGR chromosome lowers initiation rates.
Takeaway
In mice, some genes can make it much more likely for chromosomes to swap pieces during reproduction, while others can make it less likely.
Methodology
The study used a PCR-based method to detect and analyze recombination products in both male and female germ lines.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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