Antitubercular Activity of Byrsonima fagifolia Compounds
Author Information
Author(s): C. T. Higuchi, M. Sannomiya, F. R. Pavan, S. R. A. Leite, D. N. Sato, S. G. Franzblau, L. V. S. Sacramento, W. Vilegas, C. Q. F. Leite
Primary Institution: Unesp, Universidade Estadual Paulista
Hypothesis
The study aims to evaluate the antitubercular activity of Byrsonima fagifolia leaves extracts and their compounds.
Conclusion
The study found that the triterpene bassic acid has potent antitubercular activity, with a minimal inhibitory concentration of 2.5 μg/mL.
Supporting Evidence
- The chloroform extract of B. fagifolia showed a MIC of 62.5 μg/mL.
- Bassic acid exhibited a very promising MIC value of 2.5 μg/mL.
- The mixture of lupeol, α-amyrin, and β-amyrin had a MIC of 31.25 μg/mL.
- Dotriacontane was identified with a MIC of 62.5 μg/mL.
- Isoniazid, a positive control, had a MIC of 0.03 μg/mL.
Takeaway
Researchers looked at a plant called Byrsonima fagifolia to see if it could help fight tuberculosis, and they found some strong compounds that might work.
Methodology
The study used bioassay-guided fractionation and the Microplate Alamar Blue Assay to test the antitubercular activity of plant extracts and isolated compounds.
Digital Object Identifier (DOI)
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