The frequency of the predominant Jewish mutations in BRCA1 and BRCA2 in unselected Ashkenazi colorectal cancer patients
2001
Jewish Mutations and Colorectal Cancer Risk
Sample size: 225
publication
Evidence: moderate
Author Information
Author(s): Chen-Shtoyerman R, Figer A, Fidder H H, Rath P, Yeremin L, Meir S Bar, Friedman E, Theodor L
Primary Institution: Chaim Sheba Medical Center
Hypothesis
Do carriers of BRCA1 mutations have an increased risk for colorectal cancer?
Conclusion
The study found that specific BRCA1/2 mutations do not contribute to colorectal cancer predisposition in Ashkenazi Jews.
Supporting Evidence
- Four carriers of BRCA1/2 mutations were found among 225 patients.
- The frequency of mutations found is similar to the normal Ashkenazi population.
Takeaway
The study looked at whether certain gene mutations make Jewish people more likely to get colon cancer, and it found that they don't.
Methodology
225 unselected Ashkenazi Jewish colorectal cancer patients were tested for three common BRCA1/2 mutations.
Participant Demographics
Unselected Ashkenazi Jewish colorectal cancer patients.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website