Protective Effects of Cornus officinalis Against Liver Damage in Mice
Author Information
Author(s): Lee Nam-Hun, Seo Chang-Seob, Lee Ho-young, Jung Da-Young, Lee Jun-Kyung, Lee Jin-Ah, Song Kye Yong, Shin Hyeun-kyoo, Lee Mee-Young, Seo Young Bae, Kim Hokyoung, Ha Hyekyung
Primary Institution: Korea Institute of Oriental Medicine
Hypothesis
Can ethanolic extracts of Cornus officinalis prevent acetaminophen-induced liver damage in mice?
Conclusion
Ethanolic extracts of Cornus officinalis can prevent liver injuries associated with acetaminophen-induced hepatotoxicity by alleviating oxidative stress.
Supporting Evidence
- ECO treatment significantly reduced plasma levels of AST, ALT, and LDH in a dose-dependent manner.
- Mice pretreated with ECO showed decreased lipid peroxidation compared to the APAP group.
- ECO treatment maintained levels of antioxidant enzymes in the liver.
Takeaway
This study found that a fruit called Cornus officinalis can help protect the liver from damage caused by a common pain reliever when given to mice.
Methodology
Mice were treated with different doses of ethanolic extracts of Cornus officinalis for 7 days before being given acetaminophen to induce liver damage.
Limitations
The study was conducted only in mice, and the effects in humans are not yet known.
Participant Demographics
Five-week-old male BALB/c mice
Statistical Information
P-Value
p<0.05 or p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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