Elevated serum matrix metalloproteinase 9 concentration predicts the presence of colorectal neoplasia in symptomatic patients
2008
Commentary on MMP-9 and Colorectal Neoplasia
Commentary
Author Information
Author(s): Belobrajdic D P, Cosgrove L J, Phatak A
Primary Institution: CSIRO Preventative Health Flagship
Conclusion
The authors question the effectiveness of using serum MMP-9 concentration to predict colorectal neoplasia based on the study's methodology and results.
Supporting Evidence
- The authors highlight that blood was collected before disease diagnosis, which reduces bias.
- They express concern over the small R2 value, suggesting a weak relationship between MMP-9 concentration and patient age.
- The authors recommend that raw data should be made available for independent verification of results.
Takeaway
This article discusses a study that tried to use a blood test to predict if someone has a certain type of cancer, but the authors think the method might not be the best.
Potential Biases
The study's design may introduce bias since it used a model fitted only on normal individuals.
Limitations
The study's predictive model may not be reliable due to a low R2 value and unclear cutoff criteria.
Digital Object Identifier (DOI)
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