Primary Prevention of Gestational Diabetes Mellitus and Large-for-Gestational-Age Newborns by Lifestyle Counseling: A Cluster-Randomized Controlled Trial
2011

Preventing Gestational Diabetes and Large Babies with Lifestyle Counseling

Sample size: 399 publication 10 minutes Evidence: moderate

Author Information

Author(s): Riitta Luoto, Tarja I. Kinnunen, Minna Aittasalo, Päivi Kolu, Jani Raitanen, Katriina Ojala, Kirsi Mansikkamäki, Satu Lamberg, Tommi Vasankari, Tanja Komulainen, Sirkku Tulokas

Primary Institution: UKK Institute for Health Promotion Research, Tampere, Finland

Hypothesis

Can lifestyle counseling prevent gestational diabetes mellitus (GDM) and large-for-gestational-age (LGA) newborns?

Conclusion

The study found that lifestyle counseling effectively reduced the birthweight of newborns but did not significantly affect the incidence of GDM.

Supporting Evidence

  • Counseling led to a significant reduction in neonatal birthweight.
  • Women in the intervention group had a lower proportion of large-for-gestational-age newborns.
  • Adherence to dietary and physical activity recommendations was associated with better outcomes.

Takeaway

Helping pregnant women eat better and exercise more can make their babies smaller, but it might not stop them from getting diabetes during pregnancy.

Methodology

A cluster-randomized trial involving lifestyle counseling on diet and physical activity for pregnant women at risk of GDM.

Potential Biases

Potential bias due to lack of blinding for participants and nurses in the usual care group.

Limitations

The study lacked sufficient power to detect a significant difference in GDM incidence due to a smaller than expected sample size and high exclusion rates.

Participant Demographics

Women aged 30 years on average, with a BMI of 26 kg/m2, and 47% were primiparous.

Statistical Information

P-Value

p=0.008 for birthweight difference, p=0.042 for LGA proportion difference

Confidence Interval

95% CI 0.71–2.62 for GDM, 95% CI −231 to −35 for birthweight

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1371/journal.pmed.1001036

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