Parental Death during Childhood and Adult Cardiovascular Risk in a Developing Country: The Guangzhou Biobank Cohort Study
2011

Parental Death during Childhood and Adult Cardiovascular Risk in a Developing Country

Sample size: 26820 publication 10 minutes Evidence: moderate

Author Information

Author(s): Schooling C. Mary, Jiang ChaoQiang, Lam Tai Hing, Zhang WeiSen, Cheng Kar Keung, Leung Gabriel M.

Primary Institution: The University of Hong Kong

Hypothesis

Is there an association between early life parental death and cardiovascular disease risk factors in a developing country?

Conclusion

Childhood emotional adversity from parental death is negatively associated with some cardiovascular risk factors, especially in men.

Supporting Evidence

  • Early life parental death was associated with lower body mass index.
  • Men showed lower waist-hip ratio and white blood cell count associated with early life parental death.
  • Childhood emotional adversity may have different impacts on cardiovascular risk factors in non-western populations.

Takeaway

If a child's parent dies, it might affect their heart health when they grow up, but in unexpected ways, especially for boys.

Methodology

Multivariable regression analysis of cardiovascular risk factors in older adults based on parental death before adulthood.

Potential Biases

Potential bias due to the use of a single measure of emotional adversity (parental death).

Limitations

Survivorship bias may exist, and the study may not be fully representative of the population.

Participant Demographics

Participants were older adults (≥50 years) from Guangzhou, China, with a majority being women.

Statistical Information

P-Value

0.01

Confidence Interval

−0.62 to −0.19 for BMI; −0.008 to −0.001 for WHR; −0.35 to −0.13 for WBC.

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1371/journal.pone.0019675

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