Effects of a High Fat Diet on Bone in Growing Rats
Author Information
Author(s): Lac Gerard, Cavalie Helian, Ebal Edmond, Michaux Odile
Primary Institution: Biologie des Activités Physiques et Sportives (BAPS), Labo Biologie B, Les Cézeaux, 63177 AUBIERE cedex, France
Hypothesis
What are the effects of a high fat diet on bone parameters in growing rats?
Conclusion
A high fat diet during the growing period negatively affects bone parameters in rats.
Supporting Evidence
- L rats had lower body mass and lean body mass compared to S rats.
- Bone mineral content, bone mineral density, and skeleton area were lower in L rats than in S rats.
- Significant correlations were noted between body composition, adiponectin, and bone parameters.
Takeaway
Feeding young rats a high fat diet makes their bones weaker and smaller.
Methodology
The study used 32 Wistar male rats divided into two groups, one fed a high fat diet and the other a standard diet, with bone parameters assessed using DXA.
Potential Biases
Potential bias in diet composition and measurement methods.
Limitations
The study was conducted on a specific strain of rats, which may limit the generalizability of the findings.
Participant Demographics
Wistar male rats, 35 days old.
Statistical Information
P-Value
p = 0.0004, p = 0.0006, p = 0.0009, p = 0.03
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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