Pulse Pressure Variation in Pigs Under Different Anesthetics
Author Information
Author(s): Oshiro AH, Fantoni DT, Otsuki DA, Rosa KT, Auler JO Jr
Primary Institution: Faculdade de Medicina da universidade de São Paulo, Brazil
Hypothesis
The study aims to compare the behavior of pulse pressure variation under desfluorane, sevofluorane, and isofluorane anesthesia.
Conclusion
Pulse pressure variation behaved similarly with different inhaled anesthetics and increased after bleeding 30% of estimated volemia.
Supporting Evidence
- Pulse pressure variation increased after a 30% hemorrhage in all anesthetic groups.
- Mean arterial pressure decreased significantly after increasing the MAC values and after hemorrhage.
- Cardiac index decreased after increasing MAC values but showed no statistical difference after hemorrhage.
Takeaway
The study looked at how different anesthetics affect blood pressure in pigs, and found that blood pressure changes after a big loss of blood.
Methodology
Twenty-four anesthetized and mechanically ventilated pigs were divided into three groups to assess pulse pressure variation and hemodynamic parameters under different anesthetics.
Participant Demographics
Anesthetized and mechanically ventilated pigs.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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