2-(Furan-2-yl)-5-(2-nitrobenzyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one
2011
Study of a New Compound for GSK 3β Inhibition
publication
Evidence: moderate
Author Information
Author(s): Huang Zhao-Hui, Chu Yong, Ye De-Yong
Primary Institution: Fudan University
Hypothesis
The study investigates the crystal structure of a new compound to understand its relationship with GSK 3β inhibitory activity.
Conclusion
The crystal structure of the compound reveals its potential as a GSK 3β inhibitor.
Supporting Evidence
- The compound was synthesized as part of research on GSK 3β inhibitors.
- The crystal structure shows a twist-boat conformation of the thiazepine ring.
- Weak hydrogen bonds stabilize the crystal structure.
Takeaway
Scientists created a new chemical compound and looked at its structure to see if it could help treat diseases like diabetes and cancer.
Methodology
The compound was synthesized through an alkaline-catalyzed reaction and its crystal structure was analyzed using X-ray diffraction.
Digital Object Identifier (DOI)
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