Genetic Profile of Egyptian Hepatocellular Carcinoma Linked to Hepatitis C Virus
Author Information
Author(s): Zekri Abdel-Rahman N, Hafez Mohamed M, Bahnassy Abeer A, Hassan Zeinab K, Mansour Tarek, Kamal Mahmoud M, Khaled Hussein M
Primary Institution: National Cancer Institute, Cairo University
Hypothesis
What are the gene expression profiles in Egyptian patients with HCV-associated hepatocellular carcinoma?
Conclusion
The study identifies genes that could serve as prognostic and diagnostic markers for HCC associated with HCV.
Supporting Evidence
- 446 genes were differentially expressed in HCC cases.
- 180 genes were up-regulated and 134 were down-regulated.
- Significant differences were found between HCC cases with and without cirrhosis.
Takeaway
Researchers looked at the genes of 17 Egyptian patients with liver cancer caused by hepatitis C and found many genes that could help in diagnosing and treating the disease.
Methodology
Gene expression profiles were studied using cDNA microarray on samples from 17 patients diagnosed with HCC.
Limitations
The study is preliminary and involves a small sample size.
Participant Demographics
All participants were Egyptian patients diagnosed with HCC associated with HCV.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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