Granzyme B in Breast Cancer
Author Information
Author(s): Hu S X, Wang S, Wang J P, Mills G B, Zhou Y, Xu H-J
Primary Institution: The University of Texas MD Anderson Cancer Center
Hypothesis
Can endogenous granzyme B be expressed in non-immune cells of breast cancer?
Conclusion
The study found that endogenous granzyme B is expressed in a subset of breast cancer cells, particularly those overexpressing the retinoblastoma protein.
Supporting Evidence
- Endogenous granzyme B was detected in breast cancer cells rather than in tumor-infiltrating lymphocytes.
- The correlation between granzyme B and pRB expression was significant.
- Three out of 25 tumors expressed high levels of both granzyme B and pRB.
Takeaway
Some breast cancer cells can make a protein called granzyme B, which is usually found in immune cells, especially when they have a certain protein called pRB.
Methodology
The study used immunohistochemical staining and Western blotting on paraffin-embedded tissue sections from breast carcinoma specimens.
Limitations
The sample size was small, which limited the statistical analysis.
Statistical Information
P-Value
<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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