Hormone Receptor Expression in Low-Grade Endometrial Stromal Sarcomas
Author Information
Author(s): Reich O, Regauer S, Urdl W, Lahousen M, Winter R
Primary Institution: University of Graz
Hypothesis
The study investigates the expression of oestrogen and progesterone receptors in low-grade endometrial stromal sarcomas.
Conclusion
The study found that oestrogen and progesterone receptor expression in low-grade endometrial stromal sarcomas is heterogeneous, which may affect hormone therapy management.
Supporting Evidence
- 71% of tumors expressed oestrogen receptors.
- 95% of tumors expressed progesterone receptors.
- ER expression was high in 14% of tumors, moderate in 19%, and low in 38%.
- 29% of tumors did not stain for ER but were positive for PR.
- 38% of tumors had high PR expression, 47% moderate, and 10% weak.
Takeaway
The study looked at how certain hormone receptors are found in a type of cancer called low-grade endometrial stromal sarcomas, and it found that these receptors can vary a lot between different tumors.
Methodology
The study analyzed archival formalin-fixed and paraffin-embedded material using immunohistochemistry to measure ER and PR expression.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website