The Synthesis and Biological Activity of Some Magnesium(II) Complexes of Quinolones
2000
Biological Activity of Magnesium Complexes of Quinolones
publication
Evidence: moderate
Author Information
Author(s): Iztok Turel, Andrej oncx, Marija Zupan6i61, Kristina Sep6i62, Tom Turk2
Primary Institution: University of Ljubljana
Hypothesis
The study aims to isolate new magnesium compounds of quinolones and compare their biological activity against different microorganisms.
Conclusion
The introduction of magnesium into the ciprofloxacin molecule significantly reduces its antibacterial activity.
Supporting Evidence
- All magnesium complexes tested were significantly less active than the parent quinolone drugs.
- The activity of quinolones is reduced when solutions are titrated with magnesium ions.
- The activity of Mgcf is about two folds lower than the activity of the reference compounds.
- MgFCI's activity is even 30 fold lower compared to FCI in some cases.
Takeaway
This study found that adding magnesium to certain antibiotics makes them less effective at fighting germs.
Methodology
The study involved synthesizing magnesium complexes of quinolones and testing their antimicrobial activity using the agar diffusion test.
Limitations
The study did not successfully prepare crystals suitable for X-ray analysis.
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