G4LDB 3.0: a database for discovering and studying G-quadruplex and i-motif ligands
2025
G4LDB 3.0: A Database for G-Quadruplex and I-Motif Ligands
publication
Evidence: high
Author Information
Author(s): Yang Qian-Fan, Wang Xu-Rui, Wang Yu-Huan, Wu Xing-Hong, Shi Run-Yu, Wang Yan-Xi, Zhu Hao-Ning, Yang Shu, Tang Ya-Lin, Li Feng
Primary Institution: Sichuan University
Conclusion
G4LDB 3.0 is a comprehensive resource that significantly enhances the study of G-quadruplexes and i-motifs by providing advanced search capabilities and a vast collection of ligands.
Supporting Evidence
- G4LDB 3.0 includes over 4800 G4/iM ligands and approximately 51,000 activity entries.
- The database features advanced search capabilities and dynamic knowledge graphs for better data visualization.
- G4LDB 3.0 addresses the increasing demand for efficient data handling and user experience.
Takeaway
This study created a new version of a database that helps scientists find and study special DNA structures and the molecules that interact with them.
Methodology
The database uses a hybrid architecture with Elasticsearch for unstructured data and PostgreSQL for structured data, allowing for efficient data retrieval and management.
Digital Object Identifier (DOI)
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