Isoniazid Causing Drug-Induced Thrombocytopenia
2011
Isoniazid Causing Drug-Induced Thrombocytopenia
Sample size: 1
publication
Evidence: high
Author Information
Author(s): Laub Donald R Jr
Primary Institution: University of Vermont College of Medicine
Hypothesis
How should a surgeon evaluate a possible case of DITP?
Conclusion
The case report provides evidence that Isoniazid can cause drug-induced thrombocytopenia, which resolved after discontinuation of the drug.
Supporting Evidence
- The patient showed a drop in platelet count after starting Isoniazid, which recovered after stopping the drug.
- The case meets the criteria for level 1 evidence of drug-induced thrombocytopenia.
- Previous reports indicate that Isoniazid can cause thrombocytopenia.
Takeaway
This study shows that a medicine called Isoniazid can make your blood platelets very low, but stopping the medicine can help fix that.
Methodology
Case report of a child who developed drug-induced thrombocytopenia after taking Isoniazid.
Limitations
This is only the second reported case of Isoniazid-induced thrombocytopenia in 50 years, suggesting rarity.
Participant Demographics
A 22-month-old female child adopted from China.
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