San-Huang-Xie-Xin-Tang Protects against Activated Microglia- and 6-OHDA-Induced Toxicity in Neuronal SH-SY5Y Cells
2011
San-Huang-Xie-Xin-Tang Protects Neurons from Toxicity
publication
Evidence: moderate
Author Information
Author(s): Shih Yu-Tzu, Chen Ing-Jun, Wu Yang-Chang, Lo Yi-Ching
Primary Institution: Kaohsiung Medical University
Hypothesis
Does San-Huang-Xie-Xin-Tang (SHXT) have neuroprotective effects against microglia-mediated neurotoxicity?
Conclusion
SHXT protects neurons from activated microglia- and 6-OHDA-induced neurotoxicity by reducing inflammation and oxidative stress.
Supporting Evidence
- SHXT inhibited inflammation in BV-2 cells by downregulating several inflammatory markers.
- SHXT increased cell viability in SH-SY5Y cells treated with 6-OHDA.
- SHXT reduced the production of reactive oxygen species in both BV-2 and SH-SY5Y cells.
Takeaway
This study shows that a traditional Chinese medicine called SHXT can help protect brain cells from damage caused by inflammation and toxins.
Methodology
The study used co-cultured BV-2 microglial cells and SH-SY5Y neuronal cells to assess the effects of SHXT on neurotoxicity induced by LPS and 6-OHDA.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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