Using Celecoxib for Pain Management After Knee Surgery
Author Information
Author(s): Huang Yu-Min, Wang Chiu-Meng, Wang Chen-Ti, Lin Wei-Peng, Horng Lih-Ching, Jiang Ching-Chuan
Primary Institution: National Taiwan University Hospital
Hypothesis
Celecoxib provides better efficacy than the use of patient-controlled analgesic (PCA) morphine for pain management after total knee arthroplasty.
Conclusion
Perioperative celecoxib significantly improved postoperative resting pain scores at 48 and 72 hours, opioid consumption, and active range of motion in the first three days after total knee arthroplasty, without increasing the risks of bleeding.
Supporting Evidence
- Resting VAS pain scores improved significantly in the celecoxib group at 48 hrs and 72 hrs after surgery.
- Active ROM increased significantly in patients receiving celecoxib, especially in the first 72 hrs.
- Opioid requirements decreased by about 40% in the celecoxib group.
Takeaway
Giving patients celecoxib before and after knee surgery helps them feel less pain and use less morphine.
Methodology
This was a prospective, randomized, observer-blind control study with 80 patients undergoing total knee arthroplasty, divided into two groups: one receiving celecoxib and the other receiving PCA morphine only.
Potential Biases
There may be a risk of bias due to the lack of a placebo group.
Limitations
The study lacked a true placebo group and only recorded data for the first seven days post-surgery.
Participant Demographics
Patients were primarily over sixty years old with primary osteoarthritis.
Statistical Information
P-Value
p = 0.03
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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