Probiotics Induce Immune Cell Apoptosis through Sphingomyelinase Activity
Author Information
Author(s): Angulo Sandra, Morales Albert, Danese Silvio, Llacuna Laura, Masamunt Maria Carme, Pultz Nicole, Cifone Maria Grazia, De Simone Claudio, Delgado Salvadora, Vila Jordi, Panés Julián, Donskey Curtis, Fernández-Checa Jose C., Fiocchi Claudio, Sans Miquel
Primary Institution: Department of Gastroenterology, Hospital Clinic, IDIBAPS, CIBER Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain
Hypothesis
Probiotic strains used in the management of inflammatory bowel disease might exert an anti-inflammatory effect by inducing immune cell death.
Conclusion
Probiotics like L. brevis and S. thermophilus can induce apoptosis in immune cells, which may help treat inflammatory bowel disease.
Supporting Evidence
- L. brevis and S. thermophilus induced significantly more apoptosis in immune cells compared to non-probiotic bacteria.
- Probiotic-induced apoptosis was enhanced in activated immune cells.
- NSMase activity was found to be ten-fold higher in probiotics than in non-probiotics.
Takeaway
Some good bacteria can help our body by making sick cells die, which can help people with gut problems feel better.
Methodology
The study measured NSMase activity in probiotic and non-probiotic bacteria and assessed their effects on immune cell apoptosis.
Limitations
The study only evaluated two probiotic strains and may not be applicable to all probiotics.
Participant Demographics
Patients with Crohn's disease and ulcerative colitis, as well as healthy volunteers.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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