EGF's Role in Gastric Cancer Cell Growth
Author Information
Author(s): Akagi M, Kawaguchi M, Liu W, McCarty M F, Takeda A, Fan F, Stoeltzing O, Parikh A A, Jung Y D, Bucana C D, Mansfield P F, Hicklin D J, Ellis L M
Primary Institution: The University of Texas MD Anderson Cancer Center
Hypothesis
EGF regulates both VEGF and NRP-1 in human gastric cancer cell lines.
Conclusion
EGF induces the expression of NRP-1 and VEGF in gastric cancer cells, suggesting a role in tumor angiogenesis.
Supporting Evidence
- Five of seven gastric cancer cell lines expressed NRP-1 mRNA.
- EGF treatment increased NRP-1 and VEGF mRNA expression in gastric cancer cells.
- NRP-1 expression was correlated with EGF-R protein expression.
Takeaway
This study found that a substance called EGF helps cancer cells in the stomach grow by making them produce more of two important proteins.
Methodology
The study examined NRP-1 and EGF-R expression in gastric cancer cell lines and evaluated the effect of EGF on their expression.
Limitations
The study does not confirm causality between EGF-R activation and NRP-1 induction.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website