Analysis of Co-occurring Domain Sets in Yeast Proteins
Author Information
Author(s): Cohen-Gihon Inbar, Nussinov Ruth, Sharan Roded
Primary Institution: Sackler Institute of Molecular Medicine, Tel Aviv University
Hypothesis
What are the principles governing the domain content of proteins in yeast?
Conclusion
The study provides a comprehensive list of co-occurring domain sets in yeast and highlights their functional and evolutionary significance.
Supporting Evidence
- The study identified 99 significant co-occurring domain sets in yeast proteins.
- 89% of the identified sets were found to be functionally coherent.
- The identified domain sets were enriched with ancient domains conserved from bacteria or archaea.
Takeaway
This study looked at how different parts of proteins work together in yeast, finding important patterns in their combinations.
Methodology
The study used a bipartite graph representation to analyze the domain content of yeast proteins and identify significant co-occurring domain sets.
Potential Biases
The reliance on the InterPro database for domain annotations may introduce bias if the database is incomplete.
Limitations
The analysis relies on accurate domain annotations, which may not cover all proteins, and the combinatorial definition of co-occurring domain sets may miss some significant combinations.
Participant Demographics
The study focused on Saccharomyces cerevisiae proteins.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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