Awareness and acceptance of human papillomavirus vaccine in the Middle East: A systematic review, meta-analysis, and meta-regression of 159 studies
2024

HPV Vaccine Awareness and Acceptance in the Middle East

Sample size: 93730 publication 10 minutes Evidence: high

Author Information

Author(s): Gulle Bugra Taygun, Kiran Pinar, Celik Saadet Goksu, Varol Zeynep Sedef, Siyve Neslisah, Emecen Ahmet Naci, Duzel Hilal

Primary Institution: Dokuz Eylul University, Izmir, Turkey

Hypothesis

What is the level of awareness and acceptance of the HPV vaccine in the Middle East?

Conclusion

The study found that HPV vaccine awareness in the Middle East is 41.7% and acceptance is 45.6%, highlighting a critical need for improved public health initiatives.

Supporting Evidence

  • HPV vaccine awareness was found to be 41.7% across the studies.
  • The pooled acceptance rate for the HPV vaccine was 45.6%.
  • Awareness was higher among healthcare workers compared to non-healthcare workers.
  • Only 0.65% of participants in a study from Palestine were aware of the HPV vaccine.
  • Studies conducted after 2017 showed no significant increase in awareness compared to earlier studies.
  • Significant differences in awareness were observed between different countries in the Middle East.
  • Most Middle Eastern countries do not include the HPV vaccine in their national immunization programs.
  • Enhancing HPV vaccine awareness is crucial to prevent potential increases in cervical cancer rates.

Takeaway

Many people in the Middle East don't know about the HPV vaccine, and even fewer are willing to get it, which is important for preventing cervical cancer.

Methodology

This study is a systematic review and meta-analysis of 159 studies conducted in 15 Middle Eastern countries, focusing on HPV vaccine awareness and acceptance.

Potential Biases

Potential publication bias was suggested by Egger’s test, although not confirmed by the trim-and-fill method.

Limitations

The included studies showed considerable heterogeneity and potential methodological flaws, which may affect the generalizability of the findings.

Participant Demographics

The studies included a combined sample of 93,730 individuals, predominantly female (81.4%) and healthcare workers (25.4%).

Statistical Information

P-Value

p<0.001

Confidence Interval

95% CI 37.4%–46.1%

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1017/S0950268824001596

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