E-cadherin and Total Protein in Bladder Cancer Patients
Author Information
Author(s): Protheroe A S, Banks R E, Mzimba M, Porter W H, Southgate J, Singh P N, Bosomworth M, Harnden P, Smith P H, Whelan P, Selby P J
Primary Institution: Imperial Cancer Research Fund Cancer Medicine Research Unit, St James's University Hospital, Leeds, UK
Hypothesis
The study examines the diagnostic and prognostic significance of soluble E-cadherin and total protein concentrations in urine from bladder cancer patients compared to benign conditions and healthy controls.
Conclusion
Urinary measurements of soluble E-cadherin are not more valuable than total protein measurements in bladder cancer diagnosis.
Supporting Evidence
- Soluble E-cadherin concentrations were significantly higher in bladder cancer patients compared to healthy controls.
- Total protein concentrations in urine were also significantly higher in bladder cancer patients than in controls.
- The benign group showed no significant difference in E-cadherin levels compared to controls.
Takeaway
The study looked at urine from people with bladder cancer and found that a certain protein level doesn't help doctors more than just looking at total protein levels.
Methodology
The study measured soluble E-cadherin and total protein concentrations in urine from bladder cancer patients, benign urological disease patients, and healthy controls.
Limitations
The study did not find significant differences between invasive and non-invasive cancers regarding E-cadherin levels.
Participant Demographics
34 bladder cancer patients, 14 with benign urological diseases, and 21 healthy controls.
Statistical Information
P-Value
P < 0.001
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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